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Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies

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Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies Published May 6, 2026 N Engl J Med 2026;394:1814-1823 DOI: 10.1056/NEJMoa2411721 Abstract Background Severe scabies, a rare parasitic skin disease characterized by abundant skin mites, may be life-threatening and poses public health concerns worldwide. A combination of standard-dose oral ivermectin and topical scabicides is r...
Patterns detected: ARC-0024 Ambiguity (the small number of neurological events reported precludes definitive conclusions about the safety profile of dolutegravir at higher doses) This study adds to the growing body of evidence supporting the use of dolutegravir as an effective and safe antiretroviral therapy for HIV-1 infection. However, the results suggest that a higher dose may not provide additional benefit in terms of viral suppression but could increase the risk of neurological events. The ...