Author Correction: Endocannabinoids facilitate reward engagement through retrograde gain control

Correction to: Nature https://doi.org/10.1038/s41586-026-10967-w Published online 26 August 2026
In the version of the article initially published, the Competing interests section was incorrect and has now been amended to “N.S., B.B.L. and M.R.B. are co-founders and members of the Scientific Advisory Board of Biosyft, LLC, and A.E.E. is the Chief Executive Officer of Biosyft, LLC. Biosyft is developing and commercializing applications related to some of the technologies described in this manuscript. While the specific findings reported here are not directly aligned with Biosyft’s current commercial activities, given the related nature of the technology and its potential applications, the authors disclose these relationships. The other authors declare no competing interests” in the HTML and PDF versions of the article.
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Marcus, D.J., English, A.E., Chun, G. et al. Author Correction: Endocannabinoids facilitate reward engagement through retrograde gain control. Nature (2026). https://doi.org/10.1038/s41586-026-11104-3
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DOI: https://doi.org/10.1038/s41586-026-11104-3

Facts Only

Marcus, D.J., English, A.E., Chun, G. et al. Authors are associated with Biosyft, LLC through co-founder/member status on the Scientific Advisory Board and CEO position, respectively. The manuscript discusses the mechanism by which endocannabinoids facilitate reward engagement via retrograde gain control. The article was published in *Nature* in 2026.

Executive Summary

The publication details concern an article titled "Endocannabinoids facilitate reward engagement through retrograde gain control," published in *Nature* in 2026. A correction was made to the competing interests section to disclose relationships involving N.S., B.B.L., and M.R.B., who are co-founders/members of the Scientific Advisory Board of Biosyft, LLC, and A.E.E., the Chief Executive Officer of Biosyft, LLC. The authors noted that while the specific findings do not directly align with Biosyft’s current commercial activities, disclosure was made due to the related nature of the technology and potential applications. Other authors declared no competing interests.

Full Take

ACADEMIC MODE: The framework presented describes a specific neurobiological pathway—retrograde gain control mediated by endocannabinoids influencing reward engagement. A crucial step for peer review would be to assess the sufficiency of the experimental evidence linking this mechanism directly to the reported outcomes, and whether the scope of the claims is appropriately constrained by the study's methodology. The novelty rests on establishing or refining this specific link within the context of reward systems. Further investigation would require examining replication efforts across different models or tissues to test the robustness of the retrograde signaling claim outside the immediate experimental context.

Author Correction: Endocannabinoids facilitate reward engagement through retrograde gain control

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