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The KMT2F histone methyltransferase interacts with the RNA polymerase I machinery to promote ribosomal RNA transcription

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This is an uncorrected proof. Figures Abstract Trimethylation of histone 3 lysine 4 (H3K4me3) is a mark of active transcription, and its regulatory role in RNA polymerase II-mediated transcription has been well-studied. However, if and how this mark regulates RNA polymerase I (RNA Pol I) is not known. Here, we used customized genome assemblies for rDNA to demonstrate that KMT2A and KMT2F bind to e...
In this study, researchers explored the distribution of H3K4me2 and H3K4me3 marks on the rDNA locus in human cells. ChIP-seq analysis revealed that these histone modifications are enriched not only at the RNA Pol I promoter and transcribed region, but also throughout the internal spacers of the rDNA repeat unit. This suggests a role for KMT2 proteins in regulating gene expression and chromatin structure at this crucial locus. The findings build upon previous studies that documented the presence ...