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Genomic and functional adaptations in the guanylate-binding protein 5 highlight specificities of bat antiviral innate immunity

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This is an uncorrected proof. Figures Abstract Bats are asymptomatic reservoirs of several zoonotic viruses. This may result from long-term co-evolution between viruses and bats, that have led to host adaptations contributing to an effective balance between strong antiviral responses with innate immune tolerance. To better understand these virus-host interactions, we combined comparative transcrip...
This study employs a robust methodological approach, combining transcriptomics, phylogenomics, and functional assays to investigate the evolution of GBP5 in bats. The use of primary cells from Myotis yumanensis provides a relevant model for studying bat immunity, and the comparative analysis across mammalian species strengthens the findings. However, the study's reliance on a limited number of bat species (10 out of over 1,400) and the focus on specific viruses (HIV, EBLV-1, VSV) may limit the g...