Abstract
The physical and social exposome affects human aging, and brain clocks may track its effects. However, most studies neglect multidomain exposures (physical, social and political) across diverse settings globally and their associations with brain aging. In this study, we characterized the associations between 73 country-level physical and social exposomal factors and multimodal brain age i...
This study sheds light on the complex interplay between various environmental, social, and personal factors contributing to cognitive decline in older adults. By employing a multifaceted approach and analyzing data from a large, diverse sample, it challenges us to reconsider traditional notions of brain health as solely determined by genetics or age. However, the research also raises important questions about the ethical implications of using comprehensive datasets that may include sensitive inf...