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Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb

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Abstract In 2022, monkeypox virus (MPXV) clade IIb emerged resulting in a global epidemic driven by human-to-human transmission, mostly through sexual contact mainly among the population of men who have sex with men. To date, published data on the circulation of MPXV clade IIb in the central African region are absent. Here we describe a case of laboratory-confirmed mpox clade IIb lineage A2.2 in P...
The detection of mpox clade IIb in the Republic of the Congo (RoC) marks a significant shift in the disease's epidemiology, highlighting the growing complexity of its transmission dynamics. The strongest version of this narrative underscores the rapid evolution of mpox, with clade IIb's emergence in West Africa and subsequent spread to Central Africa mirroring the 2022 global outbreak. The phylogenetic analysis linking the RoC strain to lineages in Sierra Leone, the USA, and Australia suggests a...