Abstract
Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragme...
This study represents a significant advancement in psychedelic neuroscience by consolidating fragmented research through a large-scale, collaborative analysis. The use of Bayesian hierarchical modeling to quantify uncertainty and robustness of effects is a strength, as it moves beyond binary statistical thresholds to provide probabilistic insights. The findings of increased connectivity between transmodal and unimodal networks, along with subcortical involvement, align with neurocognitive models...