A new study offers the first systematic test of whether DNA methylation clocks behave the way a surrogate endpoint for aging should, responding to genuine clinical benefit and remaining stable when there is none.
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S.H. is a named inventor on patents and patent applications directed at epigenetic biomarkers, including the GrimAge and PhenoAge clocks; the Regents of the University of California are the sole owners of these patents. S.H. is a founder and paid consultant of the nonprofit Epigenetic Clock Development Foundation, which licenses these patents. S.H. was a principal investigator at Altos Labs until March 2026 and holds equity in Altos Labs.
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Horvath, S. Putting epigenetic aging clocks on trial. Nat Med (2026). https://doi.org/10.1038/s41591-026-04524-1
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DOI: https://doi.org/10.1038/s41591-026-04524-1
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