The strongest version of this narrative highlights a clear and alarming shift in the epidemiology of shigellosis in the U.S., transitioning from a pediatric, drug-susceptible infection to an adult-centered, extensively drug-resistant threat. The data underscores the disproportionate impact on men, particularly those with HIV, and the lack of effective oral treatments, which poses a serious challenge to public health response. The rise of *Shigella flexneri* in XDR cases is notable, given its his...