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Diet–microbiome associations in 10,068 individuals from the Human Phenotype Project to guide personalized nutrition

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Abstract Diet is a major environmental factor influencing the human gut microbiome. However, the effects of specific foods and dietary patterns on microbial composition, diversity and function is not fully understood, limiting progress toward personalized dietary strategies. Here, leveraging 10,068 participants from the Human Phenotype Project with app-based diet logs and shotgun metagenomics, we ...
The Human Phenotype Project, a large-scale multi-institutional study, has conducted a thorough analysis of diet-microbiome associations in over 10,000 individuals. The study's findings suggest that diets rich in ultra-processed foods are linked to a less diverse gut microbiome, while diets high in fiber-rich plant-based foods promote a more diverse microbiome. This study represents a significant step in the growing field of personaliz...