Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS). New research led by Shohei Suzuki, MD, PhD, assistant professor, division of gastroenterology and hepatology, and Tomohisa Sujino, PhD, associate professor, School of Medicine, at Keio University, Japan, has now indicat...
This study presents a compelling case for the gut as a critical player in the development of neuroinflammatory diseases like MS. The strongest version of this narrative is that it provides a mechanistic link between gut immune responses and CNS autoimmunity, offering a novel therapeutic target. The research is rigorous, using both human and mouse models, and the findings are supported by multiple lines of evidence, including genetic manipulation, cellular assays, and in vivo tracking of immune c...